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Old 04-23-2013, 08:30 AM   #1
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Default recent interesting pubmed flu-articles

recent interesting pubmed influenza articles:
labrats: http://www.ncbi.nlm.nih.gov/pubmed/23604159
H9N2 in cats and dogs: http://www.ncbi.nlm.nih.gov/pubmed/23603563
DAS181: http://www.ncbi.nlm.nih.gov/pubmed/23602850
G1-H9N2 in quails and turkeys: http://www.ncbi.nlm.nih.gov/pubmed/23597652
Recent reports demonstrated that the Korean LPAI H9N2 virus underwent antigenic drift
and evolved into distinct antigenic groups and thus could escape from vaccine protection.
60% of Swedes had Pandemrix in 2009, 72% prevailing effectiveness for 2010/11
Intervention strategies combining school closure with antiviral treatment and prophylaxis
are the most cost effective strategies in terms of cost per life year saved (LYS) for all
severity categories.
N95 FFRs filtered 0.8-μm particles of both H1N1 influenza and inert origins with
more than 95% efficiency
negligable risk from starlings and sparrows for common human and swine flu
Exposure to Swine h1 and h3 and avian h5 and h9 among feral Swine in S-China, 2009.
we can predict the strain that will become dominant in the epidemic in the following year.
Imported pigs may have introduced the first classical swine influenza viruses into China.
a chart says more than 1000 words

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Old 03-29-2015, 11:11 AM   #2
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Viral illnesses such as influenza can cause or exacerbate coronary atherosclerosis
by activating inflammatory pathways
influenza vaccination reduced deaths by 61% in cardiovascular patients
Influenza (general population ?) -but not pneumococcal- vaccination gave a 24%
reduction of strokes but no reduction for transient ischemic attack.
Cohorts born during 1918 pandemic peaks later had excess non-cancer mortality
Influenza and other acute respiratory infections can act as a trigger
for AMI (acute myocardial infarction). This effect may be stronger for
influenza than for other infections.[common colds ? asymptomatic viruses ? ]

The Avian-Origin PB1 Gene Segment Facilitated Replication and Transmissibility
of the H3N2/1968 Pandemic Influenza Virus.
175 newly sequenced human and avian H2N2 virus isolates
two avian influenza H2 viruses (H2N2 and H2N3) spread efficiently between cohoused ferrets
A/swine/Missouri/2124514/2006(H2N3) and human H2N2 transmitted to naïve ferrets
by respiratory droplets.
Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2)
virus cap-snatching process.
Influenza vaccine induces intracellular immune memory of human NK cells.
Two independent studies by two separate research teams (from Hong Kong and Singapore)
failed to detect any influenza RNA landing on, or inhaled by, a life-like, human manikin target,
after exposure to naturally influenza-infected volunteers
For the Hong Kong experiments, 9 influenza-infected volunteers were recruited to breathe,
talk/count and cough, from 0.1 m and 0.5 m distance, onto a mouth-breathing manikin.
For the Singapore experiments, 6 influenza-infected volunteers were asked to breathe
(nasal/mouth breathing), talk (counting in English/second language),
cough (from 1 m/0.1 m away) and laugh, onto a thermal, breathing manikin.
All the influenza-infected volunteers had diagnostic swabs taken at recruitment that
confirmed influenza (A/H1, A/H3 or B) infection with high viral loads, ranging from
10(5)-10(8) copies/mL (Hong Kong volunteers/assay) and 10(4)-10(7) copies/mL influenza viral RNA (Singapore volunteers/assay).
a chart says more than 1000 words

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Old 03-29-2015, 06:42 PM   #3
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Australia STILL has not released a vaccine yet......... very late this year
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Old 03-30-2015, 06:32 PM   #4
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It sounds like "Swiss A" is not very scary
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Old 05-13-2015, 05:43 AM   #5
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Drinking of honeysuckle soup can prevent IAV infection and
reduce H5N1-induced mice death.
new study published in the Protein & Cell, Chen-Yu Zhang's group
at Nanjing University
Exogenous microRNAs in maternal food pass through placenta,
regulate fetal gene expression
Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses.

Homosecoiridoid alkaloids with amino acid units from the flower buds of Lonicera japonica.

Conjugates of a secoiridoid glucoside with a phenolic glucoside from the flower
buds of Lonicera japonica

Genetic characterization and authentication of Lonicera japonica Thunb. by using
improved RAPD analysis.

Effect of chito-oligosaccharide on the oral absorptions of phenolic acids of Flos Lonicerae extract.

[Screening for genes associated with natural killer cell mediated cytotoxicity in pneumonia
mice infected with influenza virus and regulation of two herbal anti-virus formulas].

Improvement of intestinal absorption of forsythoside A and chlorogenic acid by
different carboxymethyl chitosan and chito-oligosaccharide, application to Flos
Lonicerae-Fructus Forsythiae herb couple
Interaction between oseltamivir and herbal medicines used for treating avian influenza.

Systems pharmacology uncovers Janus functions of botanical drugs: activation of host
defense system and inhibition of influenza virus replication.

The structure and absolute configuration of Shuangkangsu: a novel natural cyclic
peroxide from Lonicera japonica (Thunb.).

The effect of medicinal plants used in Chinese folk medicine on RANTES secretion by
virus-infected human epithelial cells.
Common house dust mites (e.g., Dermatophagoides farinae) excrete
a serine-type (Df) protease. Dfprotease obtained from cultured
mites enhanced viral replication in vitro via proteolytic cleavage
of viral hemagglutinin (HA) into HAl and HA2, which confers potent
viral infectivity. Its potency is 2- to 5-fold higher than bovine
trypsin or human plasmin. Df protease also markedly accelerated
virus propagation in vivo: A minute quantity of protease
(estimated delivered amount, 0.8–3.2 µg) produced ∼4- to 100-fold
increases in infectious virus in the mouse lung.
Similar augmentation of viral replication by Df protease was
observed in ferret models of nasopharyngeal infections of
influenza virus. All extracts from ordinary house dust contained
a serine-type protease that cleaved HA into HAl
and HA2. Thus, mite protease in house dust may enhance the
pathogenesis of influenza virus.
Received January 11, 1994.
review of NPIs , Apr.2015
The combination of hand hygiene with facemasks was found to have statistically
significant efficacy against laboratory-confirmed influenza while hand hygiene alone did not.

An office-based multimodal hand hygiene improvement intervention demonstrated a substantive
reduction in self-reported combined ARI-ILI/GI infections. 31% reduction

the risk of rhinovirus, rotavirus or norovirus infection after the intervention was reduced
by 47–98% (with hand sanitizer) depending upon the initial concentration of virus on the hands.
low 25OHD levels are strongly associated with ARIs in USA
a chart says more than 1000 words

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Old 06-24-2015, 01:14 AM   #6
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the full genome of the 1918 virus was determined at high coverage
in one high-throughput sequencing run of a cDNA library derived
from total RNA of a 1918 FFPE sample after duplex-specific nuclease
treatments. This basic methodological approach should assist in the
analysis of FFPE tissue samples isolated over the past century from
a variety of infectious diseases.
a chart says more than 1000 words
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Old 07-12-2015, 07:08 AM   #7
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Emerflu [Sanofi's H5N1-vaccine of 2009 , http://www.tandfonline.com/doi/pdf/1.../hv.6.10.12915 ]
is symbolic of the failure of aluminum salts as an adjuvant for influenza vaccines
newer adjuvants such as MF59 and AS03 have since demonstrated safety and superior
immunogenicity with lower HA doses.

http://scholar.google.de/scholar?cit... dt=0,5&hl=en

Vaccination against influenza: role and limitations in pandemic intervention plans
T Rebmann, A Zelicoff - 2012 - informahealthcare.com

Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind,
randomised, placebo-controlled Phase I trial
O Pleguezuelos, S Robinson, GA Stoloff… - Vaccine, 2012 - Elsevier

HTML][HTML] Advances and future challenges in recombinant adenoviral vectored H5N1 influenza
vaccines J Zhang - Viruses, 2012 - mdpi.com

A phase II, randomised clinical trial to demonstrate the non-inferiority of low-dose
MF59®-adjuvanted pre-pandemic A/H5N1 influenza vaccine in adult and elderly …
H Czajka, S Unal, S Ulusoy, G Usluer, A Strus… - Journal of preventive …, 2015 - jpmh.org

[HTML][HTML] Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets
against highly pathogenic influenza intranasal and intratracheal challenge
AJ Mann, N Noulin, A Catchpole, KJ Stittelaar… - 2014 - dx.plos.org

Use of recombinant flagellin in oil-in-water emulsions enhances hemagglutinin-specific
mucosal IgA production and IL-17 secreting T cells against H5N1 avian …
CH Lai, N Tang, JT Jan, MH Huang, CY Lu, BL Chiang… - Vaccine, 2015 - Elsevier

Adenovirus-Based Vectors for the Development of Prophylactic and Therapeutic Vaccines
AV Borovjagin, JG Gomez-Gutierrez, H Shirwan… - Novel Technologies for …, 2014 - Springer




good review Feb. 2015: (Rimmelzwaan etc.) with lots of links:


[automatic hyperlinking doesn't work here ?!]


> Clearly, currently available influenza virus vaccination strategies
> leave a lot to be desired.
> ... [novel approaches show] theoretical promise
> ... [but] we haven't quite nailed it yet.

Clinical trials have so far been only moderately successful
[135,136,137], since plasmid DNA was poorly immunogenic
in humans.
a chart says more than 1000 words

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Old 07-26-2015, 02:05 PM   #8
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> The vaccine consisted of a mixture of VLPs individually displaying H1, H3, H5, or H7 HAs,
> and vaccinated mice showed significant protection following challenge with influenza
> viruses expressing 1918 H1, 1957 H2, and avian H5, H6, H7, H10, and H11 hemagglutinin subtypes.
> These experiments suggest a promising and practical strategy for developing a broadly
> protective “universal” influenza vaccine.
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Old 08-07-2015, 09:59 AM   #9
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bats in Ghana were positive for influenzaA-H9-antigen

European tests in bats for flu were negative
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Old 11-16-2015, 01:14 PM   #10
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2015/11/16,85090 articles at pubmed for influenza, my picks from the last 360:
Seasoned soldiers experienced 82.5% protection from illness due to P&I illness in the fall,
and 84% protection from death.The morbidity data for the soldier population of Ontario,
data unavailable for civilians, confirms the presence of a herald wave in Ontario.
The findings support the hypothesis that exposure to influenza during the first wave
of the pandemic had a protective effect during the second more deadly wave in the fall.
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.
No evidence of 1918 influenza pandemic origin in Chinese laborers/soldiers in France.
influenza viruses were most sensitive to PAA/HP treatment
mixture of peroxyacetic acid and hydrogen peroxide (PAA/HP) [gaseous]
Influenza, not Ebola, More Likely the Cause of 430 bce Athenian Outbreak.
asymptomatic influenza estimates: 4%-28%, 65%-85%
increasing evidence from observational studies that influenza infection is associated with AMI.
(acute myocardial infarction)
Recent influenza infection, influenza-like illness or respiratory tract infection was significantly
more likely in AMI cases, with a pooled OR 2.01 (95% CI 1.47 to 2.76). Influenza vaccination
was significantly associated with AMI, with a pooled OR of 0.71 (95% CI 0.56 to 0.91),
equating to an estimated vaccine effectiveness of 29% (95% CI 9% to 44%) against AMI.
whereas influenza RNA copies were well preserved, the number of viable viruses decreased
by a factor of 10^4-10^5 in aerosols
Japan,2013, median durations of fever were 32.0, 41.0, and 50.0�h,
median durations of symptoms were 74.5, 85.0, and 95.0�h for A(H1N1)pdm09, A(H3N2), and B,
(with laninamivir treatment ?)
Generation of Live Attenuated Influenza Virus by Using Codon Usage Bias.
Fan RL, Valkenburg SA, Wong CK, Li OT, Nicholls JM, Rabadan R, Peiris JS, Poon LL
over 300 silent mutations were introduced into the genome of a seasonal H1N1
significantly attenuated in mammalian cells and mice, yet it grew well in embryonated eggs
protect mice
High-Dose Inactivated Influenza Vaccine can Reduce Costs and Improve Outcomes
Compared to Standard-Dose Inactivated Influenza Vaccine in Canadian Seniors.
Highly Pathogenic Avian Influenza H5N8 in Germany: Outbreak Investigations.
Implementation of new approaches for generating conventional reassortants for
live attenuated influenza vaccine based on Russian master donor viruses.
-------------added on 2015/11/20 : --------------------------------------
Difluorosialic acids, potent novel influenza virus neuraminidase inhibitors, induce fewer
drug resistance-associated neuraminidase mutations than does oseltamivir.
Platelet interactions with viruses and parasites
http://journals.lww.com/bloodcoagula...tion.22 .aspx
Wiwanitkit V. Swine flu: any effect on the platelets?
Some studies about the adherence of S. pneumoniae indicated that platelet-activating factor
receptor (PAFR), which can be expressed on the lung epithelial cell, and binds to the cell wall
component of bacteria is up-regulated by influenza infection
Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1
a chart says more than 1000 words

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Old 11-20-2015, 07:15 AM   #11
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without reading the whole paper ..., this doesn't make much sense to me.

> H1N1 viruses of avian origin have also caused 3 of 5 pandemics.

I'd say probably only 1, that of 1918 (H1). And partially (N1) that of 2009.
1889 - probably avian H3N2
1957 - avian segments 2,4,6 reassorted into the 1918 virus probably from an avian H2N2-virus
1968 - avian segments 2,4 reassorted into the 1957 virus probably from an avian H3Nx
2009 - avian segments 6,7 into Eurasian swine (ES) in 1979 and then into
"triple-reassortant-North-American-swine (TA) in ~2008 to form 2009 pandemic Mexflu (MX)
avian segments 1,3 from ~1990 into TA in ~1998 and then into MX in 2008
avian segment 2 from 1968 into TA in ~1998 (meanwhile human) and then into MX in 2008
avian segments 4,5,8 into swine in ~1912 and then into TA in ~1997 and then into MX in ~2008

> PB2 and PA (segments 1,3) from North American avian H1N1 were reintroduced to swine
> multiple times, resulting in different lineages that led to the emergence of the 2009 H1N1 IAVs.

probably not from avian H1N1, but from other avian strains. Most of the "introductions" were short-lived
and died out, only one of the introductions (of course) went into TA and then into MX

> The genotype of avian H1N1 IAVs of Charadriiformes [waders,gulls,auks] origin isolated in 2009
> differs from that of avian H1N1 IAVs of Anseriformes [ducks,geese] origin.

many different genomes , charadrii as well as anseri, which frequently mix. Origin is in mallards,
other birds got it from mallards some years ago (or decades as for gulls)

> the evolutionary process within the H1N1 IAV subtype suggests

there is no evolution "within H1N1" , all the 8 avian segments evolved independently and mixed
(reassorted) and H1N1 subtypes were relatively rare. Most prominents H3N8,H4N6.

> that the circulation of H1N1 IAVs in wild birds poses a continuous threat for future
> influenza pandemics in humans.

Especially the origin of H1 in 1918 is unclear and distant to all known avian H1.
(except some rare cases when turkeys got a swine virus, which then died out)
Those HAs no longer exist, every H1 that we see in birds is so much different
from it, that we can't really say that "H1N1 in wild birds" poses some threat
different from any other subtype. (IMO).
It makes not much sense to separate avian H1N1 from other subtypes and
to examine them separately.


Influenza Virus Reassortment Is Enhanced by Semi-infectious Particles but Can Be Suppressed
by Defective Interfering Particles

, for influenza A virus (IAV), a proportion of these seemingly non-infectious particles
are in fact semi-infectious.
Platelets replicate and produce infectious Dengue virus.
Dengue virus binds directly to platelets using DC-SIGN and
heparan sulfate proteoglycan as primary receptors.

HIV [49], influenza [50], dengue [51] and hepatitis C virus [52] have been found inside platelets
We do not support the infection hypothesis for arteriosclerosis,
We do believe the role of inflammatory processes (not necessarily infective)
in the genesis and progression of atherosclerosis (1).
atherosclerosis as a systemic inflammatory disease
but never of atherosclerosis as caused by microorganisms
systemic inflammatory response originated by pneumonia and influenza infection
that aggravates atherosclerosis burden
the microorganism theory having been refuted long ago (4).

statins as antithrombotic drugs

upregulation implicated in myocardial injury in patients with pneumonia

effects of antibiotic therapy on outcomes of patients
with coronary artery disease [2005]
Blood platelets being also innate immune cells
Platelets express pathogen recognition receptors that can sense bacterial and viral moieties
platelets capable of either binding viruses or even to be infected by some of them
a chart says more than 1000 words

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Old 12-19-2015, 04:51 AM   #12
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[2015/12/19, 86004 influenza articles in total, <200 of the most recent searched]

Similar to the previously reported peptides from retro and filoviruses the influenza fusion peptide
had immune suppressive activity when presented as a dimer but not as a monomer
Individual study results suggest ]hand washing] interventions may reduce children's absence,
RT [respiratory tract] infection incidence and symptoms, and laboratory confirmed influenza-like illness.
... evidence of the effect of hand hygiene interventions on infection incidence in educational settings
is mostly equivocal [mehrdautig] but they may decrease RT infection among children.
50% probability of the basic reproduction number (R 0) exceeding 1 for small-size influenza
droplets of 3-4 mym, implicating a potentially high indoor infection risk to humans.
However, a combination of public health interventions with enhanced ventilation could
substantially contain indoor influenza infection.
. In Canada, google flu trendes represented traditional surveillance data and corresponded
temporally with patterns in circulating respiratory viruses.
Antigenic Maps of Influenza A(H3N2) Produced With Human Antisera Obtained After Primary Infection
screening of more than 50,000 compounds ...FA-583 and FA-617, act as fusion inhibitors
Seasoned soldiers in Ontario experienced 82.5% protection from illness due to P&I illness
in the fall of 1918, and 84% protection from death.
coffee drinkers, as compared with nondrinkers, had lower hazard ratios for overall mortality
Similar findings were observed for decaffeinated coffee and coffee additives.
Inverse associations were observed for deaths from heart disease, chronic respiratory diseases,
diabetes, pneumonia and influenza, and intentional self-harm, but not cancer
Human saliva showed higher hemagglutination inhibition (HI) and neutralization (NT) titers
against seasonal influenza A virus and the pandemic H1N1 viruses than against influenza
B virus and most avian influenza viruses, except for H9N2 and H12N9
.HAI and NAI titers after vaccination decreased slowly over 18 months; overall, a 2-fold decrease
in antibody titer was estimated to take >600 days for all HA and NA targets.
["2 fold decrease" means that they only have 50% or 33% after 600days ?]
Rates of decline were fastest among inactivated virus vaccine recipients, explained in part
by faster declines with higher peak postvaccination titer.
IIV and LAIV recipients vaccinated 2 consecutive years exhibited significantly lower HAI titers
following vaccination in the second year, but rates of persistence were similar
[ --> vaccinate only every 2nd year ?]
Influmeter - an online tool for self-reporting of influenza-like illness in Denmark.
Quantifying the risk of pandemic influenza virus evolution by mutation and re-assortment.
Reperant LA, Grenfell BT, Osterhaus AD
Vaccine. 2015 Dec 8; 33(49): 6955-66
immunocompromised individuals are at high risk of generating IAV variants with pandemic
potential by accumulation of mutations.
The prevention or limitation of zoonotic IAV infection in immunocompromised and contact
individuals, including health care workers, as well as vaccination against seasonal
IAVs-limiting the risk of co-infection-should be considered fundamental tools to thwart
the evolution of a novel pandemic IAV by accumulation of mutations and re-assortment.
Will there ever be a new influenza pandemic and are we prepared?
["not if but when"]
influenza infection induces platelet-lung endothelial adhesion via fibronectin, contributing
to mortality from acute lung injury.
platelet inhibition may constitute a novel therapeutic strategy
A/California/07/2009 pandemic H1N1 (2009 pH1N1) virus with de-optimized HA and NA
gene segments (2009 pH1N1-(HA+NA)(Min)),
grew to a similar titer in MDCK cells despite reduced HA and NA protein expression
seroconversion in all ferrets and protection, no clinical illness

Identification of a Novel Viral Protein Expressed from the PB2 Segment of Influenza A Virus
We identified a new viral protein, PB2-S1, encoded by a novel spliced mRNA in which
the region corresponding to nucleotides 1513 to 1894 of the PB2 mRNA is deleted
military students with influenza before 1918 in
Australia (RR) 1·37
West Point (RR 3·10
Annapolis (RR 2·03
had increased risks of medically treated illnesses in late 1918.
Influenza virus readily aggregates with montmorillonite particles.
Influenza virus particles flattened against montmorillonite faces to increase contact area.
Virions were predominantly adsorbed to negatively charged platelet faces.
Influenza virus infectivity was not compromised despite aggregation and deformation.
new estimate of deaths in Germany from influenza pandemics:
426600 (1918/1919)
029100 (1957/1958)
046900 (1968–1970)
000350 (2009)
influenza infection induces platelet-lung endothelial adhesion
via fibronectin, contributing to mortality from acute lung injury.
The inhibition of platelets may constitute a practical adjunctive
strategy to the treatment of severe infections with influenza.
a chart says more than 1000 words

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