Go Back   This Blue Marble, a Global Current Events Discussion Forum > Health and Medicine > Ebola

Ebola News, information and discussions about prevention, spread, and treatment of Ebola. Also see our Ebola Wiki at ebola.thisbluemarble.com

Reply
 
Thread Tools Search this Thread Display Modes
Old 08-04-2014, 10:53 PM   #1
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
Default Ebola: Vaccines and Therapies

We thought it might be good to have a specific thread to discuss the various ways to prevent, treat or even cure Ebola that will be coming to the forefront during this outbreak.

I'll begin by posting what I've found so far about the ZMapp drug reportedly used on Brantly and Writebol. These are all early reports and need further verification. But they do give us a rough idea of how it may work.

-----------------------

From: http://www.defyrus.com/images/News-J...Ab-license.pdf
Quote:
DEFYRUS
NEWS RELEASE

Monoclonal Antibody-based Filovirus Therapeutic Licensed to Leaf Biopharmaceutical

Web Site Release
July 15, 2014

Toronto, ON

Today Defyrus announced an exclusive, worldwide license to their Ebola
therapeutic monoclonal antibody (mAb) patent portfolio to Leaf Biopharmaceutical Inc. of San Diego, CA. This license expands the commercial relationship between LeafBio and Defyrus who
have been actively collaborating to drive the commercialization of mAb-based Ebola therapies.

LeafBio, the commercialization partner of Mapp Biopharmaceutical, had been developing proprietary Ebola-specific antibody drug MB-003 in collaboration with the National Institutes of Health and the Defense Threat Reduction Agency (DTRA). The licensing of Defyrus’ ZMAb antibody portfolio, pioneered at the Public Health Agency of Canada (PHAC) and licensed earlier to Defyrus, consolidates the intellectual property of a superior combination mAb drug– termed ZMapp™ - which is composed of the best mAbs of MB-003 and ZMAb.

Under the terms of the exclusive, worldwide license, LeafBio assumes the commercial responsibility for the ongoing development of ZMapp™. The two companies have agreed to an equitable revenue sharing model based on ZMapp™ product sales. “Integrating key ZMAb antibody technology into our ongoing Ebola virus preclinical and planned clincial development program has been welcomed by our US government partners” stated Larry
Zeitlin, President of LeafBio. “ZMapp™ has enhanced efficacy as a treatment in our non-human primate challenge models.”
ZMapp™ antibodies are being produced under an existing manufacturing collaboration withKentucky Bioprocessing (KBP, Owensboro KY).

Using a fully automated production system thatoperates in accordance with good manufacturing practices (GMP),the antibodies are produced in Nicotiana. This high performance manufacturing process decreases production time, increases the quantity of antibody produced, and lowers
the cost of manufacturing.

“This license to LeafBio places our ZMAb technology in the hands of experienced antibody manufacturers with specific regulatory expertise and funding. We share a joint vision with LeafBio to deliver an effective treatment for Ebola virus infection on a cost effective basis globally.” said Jeffrey Turner, President & CEO Defyrus.

About Defyrus
Defyrus is a Canadian private, life sciences biodefence company that collaborates with military and public health R&D partners in the United States, Asia and Canada to develop broad spectrum anti-viral drugs, MAbs and vaccines as medical countermeasures to viral and bacterial
infectious diseases.
www.defyrus.com

About Mapp and Leaf Biopharmaceutical
Mapp Biopharmaceutical develops novel biopharmaceuticals for the prevention and treatment of infectious diseases, focusing on unmet needs in global health and biodefense. As these products transition to clinical ev
aluation, Leaf Biopharmaceutical assumes ownership and commercialization responsibilities.
www.mappbio.com, www.leafbio.com



From WebMD (not my favorite source but it has a good quote from Dr. Zeitlin.

Experimental Ebola Serum Grown in Tobacco Leaves


Quote:
The compound used to treat Dr. Kent Brantly and Nancy Writebol was only formulated in January, according to Larry Zeitlin, PhD, president of Mapp Biopharmaceuticals, the California company that co-developed the drug.

It has been tested in monkeys, but had never before been given to human patients before it was rushed to Brantly and Writebol.

Zeitlin says he hasn’t even had a chance to publish a scientific paper on the compound, which is a combination of three antibodies that are thought to help in two ways.

One of the antibodies alerts the immune system to infected cells so they can be destroyed, says Erica Ollmann Saphire, Ph.D. She's a professor of immunology at the Scripps Research Institute in La Jolla, CA. She’s been given a government grant to study the antibody cocktail.

Saphire says the other two antibodies probably prevent the virus from making more copies of itself. “We’re still trying to figure out exactly how it works,” she says. “But it seems to neutralize the virus.”


Finally, a long but interesting piece from Science Blogs.

GMO viruses + bacteria + GMO tobacco likely saved Ebola patients

Quote:
ZMapp itself is a combination of the ‘best’ antibodies from MB-003 and ZMAb. How do I know this? Because this is information released by the company this July. And MB-003 and ZMAb are not exactly ‘secret’, seeing as they were published in two of the most high profile journals in the world, PNAS and Science.

What I think is super cool is how this therapy is made.

1a. Genetically modify a virus to encode the heavy chain of an anti-Ebola antibody. These antibodies are also genetically modified, btw, to not be as ‘mouse-like’ (they were initially produced in mice) and sometimes to be more ‘human-like’. Putting antibodies from other animals into humans without genetic modification can mean trouble.

1b. Genetically modify a virus to encode the corresponding light chain of the anti-Ebola antibody.

WHY??

When both of these viruses infect a cell, one viral genome will make half the anti-Ebola antibody, the other viral genome will make the other half of the antibody. Together, the two viruses will make the anti-Ebola antibody!

2a. Put these GMO viral components into a bacteria, Agrobacterium tumefaciens.

2b. Infect a plant, like tobacco, with the Agrobacterium tumefaciens.

WHY??

You could just infect the plant with the viruses. So why introduce the bacteria into the equation? Because the viruses kinda suck at replicating in the plants. The bacteria helps get the viral genomes to as many parts of the plant as possible, which means lots and lots of cells in the plant are producing antibodies. This bumps up how much antibody you can purify from a single plant by a LOT.

3a. Infect GMO Nicotiana benthamiana with the bacteria.

3b. Wait.

3c. Purify your anti-Ebola antibodies.

WHY??

Plants are not people. In this case, Nicotiana benthamiana was genetically modified to inhibit the enzymes that make plant sugars plant-like, meaning the anti-Ebola antibodies will have more human-like sugars on the surface. This can be really important for some of the anti-viral properties of the antibodies.

After this genetic modification and infection with the bacteria+viruses, the plant leaves will produce a TON of anti-Ebola antibodies. Plants are a pretty cheap way to produce a lot of protein. Blow up the plant cells, purify your protein, and BAM!

A ton of anti-Ebola antibodies.

Do that with three different anti-Ebola antibodies, mix the antibodies together for an anti-Ebola cocktail, give them to people to see if it helps.

And indeed, if this therapy does prove to play an integral role in ‘saving’ these two US Ebola patients, we probably have a fairly cheap, readily up-scalable and modifiable way to treat the current Ebola epidemic.
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
The Following 3 Users Say Thank You to Catbird For This Useful Post:
AndreaCA (08-04-2014), Justathought (08-06-2014), linttrap (08-05-2014)
Old 08-04-2014, 11:04 PM   #2
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
An article in an Arizona State U publication - not a peer reviewed journal - dated Dec. 2011, gives some further detail on the development of ZMapp.

Moving toward an Ebola vaccine
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-05-2014, 03:08 PM   #3
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
Interesting.


From: GSA - FebBizOps


MB-2003: An Ebola Virus Countermeasure
Solicitation Number: HDTRA1-13-C-0018-P00003
Agency: Other Defense Agencies
Office: Defense Threat Reduction Agency

Original Synopsis
Jul 22, 2014
1:36 pm


Solicitation Number:HDTRA1-13-C-0018-P00003
Notice Type:Presolicitation

Synopsis:
Notice of Intent to Award a Sole Source Contract

The Defense Threat Reduction Agency (DTRA) intends to negotiate and award a sole source modification to current contract HDTRA1-13-C-0018 to MAPP Biopharmaceutical. This is follow-on research to a current contract which focuses on development of a monoclonal antibody cocktail for Ebola Zaire. The proposed work comprises specific, additional tasks which are justified by the promising results from the work already conducted under the current contract. The two additional tasks are 1) to prepare and submit an Investigational New Drug (IND) application package to the Food and Drug Administration (FDA) for ZMappTM, and 2) to provide cGMP grade ZMappTM in sufficient quantity to perform a Phase 1 clinical safety study. The additional tasks will be performed within the current period of performance of 12 months...
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-05-2014, 09:39 PM   #4
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
For anyone who is interested in some more technical info, here's an archive of articles dealing with the MB003/ZMapp antibody.

Science Translational Medicine Ebola
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
The Following User Says Thank You to Catbird For This Useful Post:
Exodia (08-09-2014)
Old 08-06-2014, 01:33 AM   #5
Justathought
Member
 
Justathought's Avatar
 
Join Date: Sep 2008
Location: Western Washington
Posts: 190
Thanks: 26
Thanked 22 Times in 17 Posts
DO'NT BELIEVE EVERYTHING YOU HEAR (or read). Reporters get it wrong. People lie or misconstrue.

All we can do here is gather information and report it. We connect the dots; trying to put things together to make a logical whole. It annoys me when we get it wrong because we had the wrong information, etc.

TREATMENT

We were told there was only one dose of the "serum" available last week, and Dr. Bradley insisted it be given to his co-worker, Nancy. In fact, apparently Dr. Bradley did receive a dose of the serum (ZMapp), before he left for the U.S. and he showed rapid, remarkble improvement. CNN reported (and I only heard it once) that Dr. Bradley received a Blood transfussion to help get him ready for the long air flight. It was from an Ebola-recovered young man he had treated. It was hoped that there would still be Ebola antibodies in his blood which could help Dr. Bradley.

Nancy, on the other hand, recieved two doses of ZMapp before leaving for the U.S. She apparently showed some improvement on one dose and much more after the second dose. She is due to receive a third and final dose tomorrow (Wen).

IS THIS TRUE?

Was there a blood transfusion? Did it effect Dr. Bradely's rapid improvement? Did it affect the ZMapp treatment? Does the CDC have any other "experimental" treatments they want to try to further muddy the waters? It does'nt matter to Dr. Bradely and Nancy. They are dead anyway without a lot of luck and some effective Ebola treatment. However, it could be Life and Death for thousands in the rest of the world.

MONEY

It is encouraging to see in one of the above posts, that the Grant and Contract money is already flowing (DOD/Darpa?) to speed up ZMapp development and testing etc.



Last edited by Justathought; 08-06-2014 at 04:23 PM.
Justathought is offline   Reply With Quote
Old 08-06-2014, 03:16 AM   #6
Justathought
Member
 
Justathought's Avatar
 
Join Date: Sep 2008
Location: Western Washington
Posts: 190
Thanks: 26
Thanked 22 Times in 17 Posts
Quote:
From Catbird: The Defense Threat Reduction Agency (DTRA) intends to negotiate and award a sole source modification to current contract HDTRA1-13-C-0018 to MAPP Biopharmaceutical. This is follow-on research to a current contract which focuses on development of a monoclonal antibody cocktail for Ebola Zaire. The proposed work comprises specific, additional tasks which are justified by the promising results from the work already conducted under the current contract. The two additional tasks are 1) to prepare and submit an Investigational New Drug (IND) application package to the Food and Drug Administration (FDA) for ZMappTM, and 2) to provide cGMP grade ZMappTM in sufficient quantity to perform a Phase 1 clinical safety study. The additional tasks will be performed within the current period of performance of 12 months...
The ZMapp money is apparently not coming out of the DOD Darpa budget. It is sponsored by DOD's newest research and special project office, charged with chemical and biological defense (among other things). The Defense Threat Reduction Agency (DTRA).

An interesting website, DTRA:

http://www.dtra.mil/Missions/Chemica...fenseHome.aspx



Last edited by Justathought; 08-06-2014 at 04:24 PM.
Justathought is offline   Reply With Quote
Old 08-06-2014, 07:50 AM   #7
CanadaSue
SuperModerator
 
CanadaSue's Avatar
 
Join Date: Nov 2008
Location: In my gardens or online
Posts: 35,508
Blog Entries: 28
Thanks: 2,486
Thanked 11,047 Times in 5,057 Posts
Default Don't Forget the Snake Oil

***#BBCtrending: The Ebola 'cure' that offers false hope


A message declaring that a plant can "cure" Ebola is being widely shared via mobile phone in West Africa - but the claim is not true, and may be offering false hope to those living amidst the outbreak.

"Bitter-Kola has been internationally verified to cure Ebola", reads the note, which is being circulated on messaging apps and other social media. "Pls do not forget to share cheers!!!" it concludes. Bitter-Kola is another name for Garcinia kola - a plant that grows in parts of West Africa and has been used for centuries in folk medicine to treat colds and fevers. Stories suggesting that the plant holds the key to a cure have also been reported in some parts of the African media, raising hopes further still. So where did the idea come from, and how has it taken hold?...***


More at link:


http://www.bbc.com/news/blogs-trending-28665324
__________________
Searching for a dream to run after & catch!
CanadaSue is offline   Reply With Quote
Old 08-08-2014, 05:42 PM   #8
CanadaSue
SuperModerator
 
CanadaSue's Avatar
 
Join Date: Nov 2008
Location: In my gardens or online
Posts: 35,508
Blog Entries: 28
Thanks: 2,486
Thanked 11,047 Times in 5,057 Posts
Default ZMAPP - Full Business Insider Article

An interesting read. Two things jumped out at me - to make it you have to infect mice with Ebola - pretty hefty inherent risks there. Secondly, it works best given close to exposure.

http://www.businessinsider.com/zmapp...#ixzz39k4g1c3y


Both of the EVD-infected U.S. citizens in Liberia received a rare dose of what news reports called a "secret serum" to treat the virus before being transported to Emory University Hospital in Atlanta, USA according to a CNN report. And while some people do fight off the disease on their own, in the case of the 2 Americans, that experimental serum may have saved their lives.

As KB and missionary NW waited in a Liberian hospital, someone from the U.S. National Institutes of Health reached out to Samaritan's Purse, one of the 2 North Carolina-based Christian relief groups the 2 were working with, and offered to have vials of an experimental drug called ZMapp sent to Liberia, according to CNN's unnamed source.

Although the Food and Drug Administration does allow experimental drugs to occasionally be distributed in life-threatening circumstances without approval under the expanded access or "compassionate use" conditions, it's not yet clear whether that approval was granted in this case or not. A spokesperson for the FDA told Business Insider that federal law and FDA regulations prohibit them from commenting on specific products, as that information is considered confidential.

An Emergency Treatment
------------------
However, it was approved, 3 frozen vials of ZMapp, a drug being developed by Mapp Biopharmaceutical, were flown to Liberia and arrived the morning of Thu 31 Jul 2014. The serum needed 8-10 hours to thaw. KB, who had been sick for 9 days already, reportedly had asked that NW receive the 1st dose, as he was younger and thought he had a better chance of surviving [It's unclear from the CNN story why the doses apparently were not all ready at the same time]. But his condition worsened as the 1st dose thawed, and CNN reports that he told his doctors, "I am going to die."

He asked for the 1st dose and had it given to him through an IV. According to CNN's source, within an hour, he was able to breathe better and a rash on his body started to fade. The next day he was able to shower without help before boarding the air ambulance that flew him to Atlanta, USA.

NW reportedly didn't respond as well to the 1st treatment she received and had to be given the 3rd vial of serum. Her 2nd treatment seemed to improve her condition, according to CNN and stabilized her enough that she is expected to fly to the USA on Tue 5 Aug 2014 [which she did].

The ZMapp serum itself is what is known as a "monoclonal antibody." These substances are created by infecting an animal with the disease in question. Then, scientists harvest and use the antibodies that the animals' immune systems create to fight the virus. In this case, the antibodies were harvested from ebolavirus-infected mice.

Studies have tested various other blends of similar therapies against ebolavirus-infected monkeys before, with some efficacy, but only when the therapy is given within 48 hours of infection. As Hamblin cautions, "very little is known about the safety and effectiveness of this treatment, so little that outside of extreme circumstances like this, it would not be legal to use."

This EVD outbreak -- the worst in history -- has already killed [932] people. But promising news of an experimental serum doesn't mean that a treatment is close. Developing a cure for a virus is complicated, and developing a treatment for Ebola has proven particularly difficult. In this case, since health officials can't comment on a specific treatment or on the patients involved for privacy reasons, we don't know the exact status of KB and NW or how that status has been affected by the serum that they reportedly received.

Before this emergency use, ZMapp had only been tested in a small number of monkeys. The company reported that all 4 monkeys who received the treatment within 24 hours of being infected survived. Half of another group of 4 monkeys who were treated within 48 hours survived. KB and NW had been sick much longer than that before being treated, and treatments that work in animals -- especially such a small number of animals -- routinely fail to work in human trials.

Standard "treatment" for EVD usually involves trying to keep patients hydrated and alive long enough to give the immune system a chance to battle the virus. And while that approach may sound unpromising, this outbreak has had a fatality rate of about 60 percent so far, not close to the 90 percent that's often reported. That 60 percent number could still rise, but survival cannot necessarily be attributed to an experimental treatment. While EVD is highly fatal, some people do survive without any extraordinary interventions.

ZMapp is not even far enough along to have entered the clinical trial phase, but it may have been chosen in this case instead of the promising experimental drug Tekmira, because an ongoing Tekmira trial was just halted by the FDA. That doesn't mean that all research on Tekmira is over, however. The ongoing trial was halted because healthy patients showed a problematic immune response.

But the FDA could still approve a new trial of the drug in sick patients, as the risk-benefit equation would be changed. A potential benefit of surviving a disease that kills 60-90 percent of patients could outweigh the risks of many potentially problematic side effects [It was not side effects that stopped the trial, but lack of an adequate immune response in all test humans. - Mod.JW]. CNN also reported that on 30 Jul 2014, the military approved additional funding for Mapp Biopharmaceutical because of their promising results so far.

If either ZMapp or Tekmira prove to be effective, testing, approving, and then producing a drug will still take time, even if the process is fast-tracked. At this point, the best hope for stopping this outbreak is not curing it but containing it. Even though the virus can only be transmitted by close contact, and thus it can be contained, health officials have been completely unable to do so in West Africa due to a combination of factors including poor healthcare infrastructure, distrust of authorities, traditional burial practices, and fear of healthcare providers.

At the present rate, World Health Organization chief Margaret Chan describes the consequences of not being able to stop the disease's spread as "catastrophic."

[Byline: Kevin Loria]
__________________
Searching for a dream to run after & catch!
CanadaSue is offline   Reply With Quote
The Following User Says Thank You to CanadaSue For This Useful Post:
AndreaCA (08-08-2014)
Old 08-08-2014, 06:45 PM   #9
Sonny
Star Witness
 
Sonny's Avatar
 
Join Date: Aug 2008
Location: the safe house
Posts: 5,768
Blog Entries: 1
Thanks: 1,984
Thanked 766 Times in 497 Posts
Yeah but none of those articles mention the fascinating parts how ZMapp is grown in genetically modified Tabacco plants where bacteria were used to inoculate the genetically engineered genes.

http://thisbluemarble.com/showthread.php?t=58435
catbirds posts
Quote:
The drug being credited with potentially saving the lives of two American missionaries infected with the deadly Ebola virus was produced at a facility in Owensboro.

The serum wasn't manufactured but grown, in a greenhouse full of genetically modified tobacco plants.
Sonny is offline   Reply With Quote
Old 08-09-2014, 10:14 PM   #10
Justathought
Member
 
Justathought's Avatar
 
Join Date: Sep 2008
Location: Western Washington
Posts: 190
Thanks: 26
Thanked 22 Times in 17 Posts
Above we ask,
Quote:
Was there a blood transfusion? Did it effect Dr. Bradely's rapid improvement? Did it affect the ZMapp treatment?
Dr. Gupta did a special Ebola Update program on CNN today. At one point, he interviewed Dr.Fauci, (Dr. Fauci was appointed Director of NIAID at NIH in 1984. He oversees an extensive research portfolio of basic and applied research to prevent, diagnose, and treat infectious diseases.) They discussed the blood transfusion Dr. Bradley had received before leaving Liberia.

Sanjay ask if it had had any effect on Dr. Bradley's recovery. Dr. Fauci said he did not know, and that the transfusion was only second-hand information. (They must be turning over rocks trying to find out when?, where?, and why?)

Dr. Fauci did explain the rational of a blood transfusion from a recently recovered Ebola patient, from an antibody perspective. I suspect if it did happen, it would have been a last minute, desperate attempt to save Dr. Bradley's life.

Antibodies can be harvested and injected in a number of ways, and someone is bound to experiment with a combined antibody and ZMapp treatment if ZMapp alone is not enough.

In fact, the CDC is probably looking at Dr. Bradley's antibodies right now.


Justathought is offline   Reply With Quote
Old 08-11-2014, 11:22 AM   #11
dharma
Git it, booger.
 
Join Date: Sep 2008
Posts: 5,645
Thanks: 1,130
Thanked 2,711 Times in 1,053 Posts
Ebola vaccine.

http://www.reuters.com/article/2014/...me=companyNews
dharma is offline   Reply With Quote
Old 08-11-2014, 12:19 PM   #12
Exodia
Khan of the Golden Horde
 
Exodia's Avatar
 
Join Date: Aug 2008
Location: Southeast PA
Posts: 11,292
Thanks: 2,632
Thanked 4,866 Times in 2,184 Posts
From a scientific point of view, I'm not sure there is a lot to learn from the one-off cases, where multiple things were tried, different timing and variables for each. No controls, multiple operators.

Hopefully one can gleam some insight (needle in a haystack?), and put that into a properly designed experiment.
__________________
"Now, mark my words. So long as we are a young and virtuous people, this instrument will bind us together in mutual interests, mutual welfare, and mutual happiness. But when we become old and corrupt, it will bind us no longer" - Alexander Hamilton about the US Constitution.
Exodia is offline   Reply With Quote
Old 08-12-2014, 01:24 PM   #13
Exodia
Khan of the Golden Horde
 
Exodia's Avatar
 
Join Date: Aug 2008
Location: Southeast PA
Posts: 11,292
Thanks: 2,632
Thanked 4,866 Times in 2,184 Posts
Quote:
Attack Ebola on a nanoscale

The Ebola virus out*break in West Africa has claimed more than 900 lives since February and has infected thousands more. Countries such as Nigeria and Liberia have declared health emergencies, while the World Health Organization began a two-day meeting last Wednesday to discuss ways to battle the outbreak.

There is no known vaccine, treatment, or cure for Ebola, which is contracted through the bodily fluids of an infected person or animal. But that doesn’t mean there’s not hope. In fact, Chemical Engineering Chair Thomas Webster’s lab is currently working on one possible solution for fighting Ebola and other deadly viruses: nanotechnology.

“It has been very hard to develop a vaccine or treatment for Ebola or similar viruses because they mutate so quickly,” explained Webster, the editor-in-chief of the International Journal of Nanomedicine. “In nanotechnology we turned our attention to developing nanoparticles that could be attached chemically to the viruses and stop them from spreading.”

One particle that is showing great promise is gold. According to Webster, gold nanoparticles are currently being used to treat cancer. Infrared waves, he explained, heat up the gold nanoparticles, which, in turn, attack and destroy everything from viruses to cancer cells, but not healthy cells.

Recognizing that a larger surface area would lead to a quicker heat-uptime, Webster’s team created gold nanostars. “The star has a lot more surface area, so it can heat up much faster than a sphere can,” Webster said. “And that greater surface area allows it to attack more viruses once they absorb to the particles.” The problem the researchers face, however, is making sure the hot gold nanoparticles attack the virus or cancer cells rather than the healthy cells.

In addition to the gold nanostars, Webster’s lab is also generating a nanoparticle that would serve as a “virus decoy,” chemically attracting the virus to attack it rather than healthy cells.

While Webster’s lab has been working in nanotechnology for about 15 years, it was not until recently that his lab started to explore the benefits of nanomedicine.

“We realized the potential,” Webster said, noting that his student researchers use synthetic analogs that mimic viruses’ structures. “There is obviously such a huge need right now for ways to treat Ebola and other viruses, and it’s up to us to study and look at new and creative ways that traditional medicine really can’t.”
http://www.nanomagazine.co.uk/index....=38&Itemid=159
__________________
"Now, mark my words. So long as we are a young and virtuous people, this instrument will bind us together in mutual interests, mutual welfare, and mutual happiness. But when we become old and corrupt, it will bind us no longer" - Alexander Hamilton about the US Constitution.
Exodia is offline   Reply With Quote
Old 08-12-2014, 05:26 PM   #14
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
Ebola: FG, Canada, China, Italy to Collaborate on Production of Antibodies

Quote:
The federal government, through the National Biotechnology Development Agency (NABDA), an agency under the Federal Ministry of Science and Technology, yesterday in Abuja, disclosed that it had concluded arrangements with Canada, China, Korea and Italy to produce antibodies against the killer Ebola Virus Disease (EVD), using a biotechnological device.

According to government, this appears to be the immediate antidote to curtailing the spread of the disease, pending when a permanent solution will be found.

The Director General, NABDA, Prof. Lucy Ogbadu, spoke with THISDAY at the sidelines of a workshop on Theoretical and Practical Course on Plant Tissue Culture, organised by the agency in conjunction with an Italian based donor agriculture agency: the International Centre for Genetic Engineering and Biotechnology (ICGEB) . She said diagnostic kits for the disease developed by Korea, for Nigeria would arrive the country today.

She said: “As matter of fact, when Ebola first broke out this time in other parts of Africa, the Western world sequenced the Ebola and immediately this was sequenced, we got the information and got our counterpart in Korea to develop diagnostic kits for NABDA, the kits will arrive Nigeria tomorrow.”

... Explaining how the antibodies will fight the virus, she said: “The immediate thing is to look at those who have survived or recuperating from the disease, because, that is where you can get antibodies. The people who are going through the disease are constantly producing antibodies. “It is just that the viruses may overwhelm their system. So if we are able to screen their system, we should be able to get antibodies. We would then be able to harvest these antibodies and multiply them for use until a permanent solution is found.”

Corroborating the DG in a remark, a Director in the agency, who requested anonymity said: “My DG has asked me to tell you that we are also working on the Ebola Virus Disease (EVD). On the 23rd of this month, we are partnering with foreign agencies to organise a diagnostic approach to stemming Ebola, it is going to be novel.”

He said the agency is working hard to actualise its plans because the United States has refused to make available the antibodies developed by them, adding: “In addition to that there is an antibody that the U.S has refused to release, but NABDA is partnering with Canada, very soon to produce its own antibodies
...
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-12-2014, 05:35 PM   #15
CanadaSue
SuperModerator
 
CanadaSue's Avatar
 
Join Date: Nov 2008
Location: In my gardens or online
Posts: 35,508
Blog Entries: 28
Thanks: 2,486
Thanked 11,047 Times in 5,057 Posts
Hmmm...

I've got try & find the Canadian connection.
__________________
Searching for a dream to run after & catch!
CanadaSue is offline   Reply With Quote
Old 08-12-2014, 06:20 PM   #16
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
It might be Tekmira Pharmaceuticals.

Most of the other companies that I'm reading about are working on a vaccine, not a therapeutic drug.
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-12-2014, 06:34 PM   #17
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
Quote:
He said the agency is working hard to actualise its plans because the United States has refused to make available the antibodies developed by them, adding: “In addition to that there is an antibody that the U.S has refused to release, but NABDA is partnering with Canada, very soon to produce its own antibodies...

I think this might be the explanation of the American "refusal".

Ethical questions arise over experimental Ebola drug after only 3 Westerners get it

Quote:
...At least two countries in West Africa have expressed interest in the drug. Nigeria’s health minister, Onyenbuchi Chukwu, said last week he had asked U.S. health officials about access to it but was told the manufacturer would have to agree. Guinea also said Monday it would like to have some of the drug.
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-12-2014, 11:06 PM   #18
CanadaSue
SuperModerator
 
CanadaSue's Avatar
 
Join Date: Nov 2008
Location: In my gardens or online
Posts: 35,508
Blog Entries: 28
Thanks: 2,486
Thanked 11,047 Times in 5,057 Posts
Exclamation Woah!

***Canada offers experimental Ebola vaccine VSV-EBOV to West Africa***

(This is a breaking story; doesn't sem related to what Catbird referenced either. Now... WHO gets its but WHO gets it?)


***A made-in-Canada experimental Ebola vaccine will be offered for use in the West African outbreak response, the Public Health Agency of Canada revealed Tuesday.

The news comes hours after the World Health Organization said a panel of experts advised that it would be ethical to use untested drugs and vaccines in this raging epidemic, which is several times larger than any previous outbreak.

"We see this as a global resource and we need to have some conversations to figure out what the best use of this experimental vaccine is," said Dr. Gregory Taylor, deputy head of the public health agency.

He said the agency would be discussing options with international partners and the WHO over the coming days to try to come up with a plan for the best use of what is a limited number of vaccine doses.

'I was pleased to offer the experimental vaccine developed by Canadian researchers as a global resource to help fight this outbreak'
- Health Minister Rona AmbroseIn a statement Tuesday, Health Minister Rona Ambrose confirmed that she spoke on the phone with WHO director general Margaret Chan about the donation.

"I was pleased to offer the experimental vaccine developed by Canadian researchers as a global resource to help fight this outbreak," she said, adding that between 800 and 1,000 doses would be donated to the WHO.

Ambrose added that "Canada feels this experimental vaccine is a global resource, so in response we are sharing it with the international community, while keeping a small supply in Canada."***

Way more at link:


http://www.cbc.ca/news/health/canada...rica-1.2734681
__________________
Searching for a dream to run after & catch!
CanadaSue is offline   Reply With Quote
The Following User Says Thank You to CanadaSue For This Useful Post:
NowVoyager (08-13-2014)
Old 08-12-2014, 11:13 PM   #19
CanadaSue
SuperModerator
 
CanadaSue's Avatar
 
Join Date: Nov 2008
Location: In my gardens or online
Posts: 35,508
Blog Entries: 28
Thanks: 2,486
Thanked 11,047 Times in 5,057 Posts
Default List of Candidate Vax & Treatments Under Development

Interestingly, the Canadian one - Tekmira, had studies halted when healthy volunteers had an unspecified 'reaction'. The FDA has since lifted that restriction:

***Ebola experimental drugs and vaccines in early days of testing***


http://www.cbc.ca/news/health/ebola-...ting-1.2734577
__________________
Searching for a dream to run after & catch!
CanadaSue is offline   Reply With Quote
Old 08-12-2014, 11:33 PM   #20
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
I posted something about this somewhere. I think the Tekmira drug induced some sort of hyper-immune state. I'll see if I can find the post.
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-12-2014, 11:58 PM   #21
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
This isn't exactly what I was looking for but it's a start. The TKM drug was in Phase 1 clinical trials. It's designed to be administered in an ascending 5 dose course. But, while still testing only a single dosage level, there were reports of an unanticipated elevation in cytokine levels.

Quote:
British Columbia-based Tekmira Pharmaceuticals TKMR -21.95% is a bit further ahead of BioCryst with a small interfering RNA molecule (encapsulated in lipid nanoparticles) against Ebolavirus RNA polymerase L protein. The drug is in phase 1 trials but was just placed on hold by the FDA last week in order to investigate the mechanism behind elevated cytokines in healthy human volunteers receiving the drug.
This Forbes article also discusses a couple of other drugs that are being tested.

http://www.forbes.com/sites/davidkro...ny-drugs-work/
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-13-2014, 06:06 AM   #22
CanadaSue
SuperModerator
 
CanadaSue's Avatar
 
Join Date: Nov 2008
Location: In my gardens or online
Posts: 35,508
Blog Entries: 28
Thanks: 2,486
Thanked 11,047 Times in 5,057 Posts
Catbird, you no doubt did post that info & I simply missed it. Some days, there is so much information, it's hard to keep straight.
__________________
Searching for a dream to run after & catch!
CanadaSue is offline   Reply With Quote
Old 08-13-2014, 11:53 AM   #23
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
I know.

There's so much that I can't even remember when or where I posted it. No biggie.
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-13-2014, 04:57 PM   #24
Catbird
Chasing my tailfeathers
 
Catbird's Avatar
 
Join Date: Mar 2011
Location: East TN
Posts: 10,860
Thanks: 5,891
Thanked 8,275 Times in 3,379 Posts
Interesting.

Ebola drug maker Tekmira halted for news pending - @CNBCnow
__________________
"I think the most un-American thing you can say is, 'You can't say that.'” Garrison Keillor

"It's not inequality which is the real misfortune, it's dependence." Voltaire
Catbird is online now   Reply With Quote
Old 08-13-2014, 05:14 PM   #25
CanadaSue
SuperModerator
 
CanadaSue's Avatar
 
Join Date: Nov 2008
Location: In my gardens or online
Posts: 35,508
Blog Entries: 28
Thanks: 2,486
Thanked 11,047 Times in 5,057 Posts
Do you mean trading? Don't know if they're a publicly trading, listed company. I have no idea.
__________________
Searching for a dream to run after & catch!
CanadaSue is offline   Reply With Quote
Reply

Tags
ebola, therapies, vaccines

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -4. The time now is 12:30 AM.


Powered by vBulletin®
Copyright © Jelsoft Enterprises Ltd.